1iru: Difference between revisions
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[[Image:1iru.gif|left|200px]] | [[Image:1iru.gif|left|200px]] | ||
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'''Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution''' | '''Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution''' | ||
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[[Category: Yasuoka, N.]] | [[Category: Yasuoka, N.]] | ||
[[Category: 20s proteasome]] | [[Category: 20s proteasome]] | ||
[[Category: | [[Category: Cell cycle]] | ||
[[Category: | [[Category: Immune response]] | ||
[[Category: | [[Category: Proteolysis]] | ||
[[Category: | [[Category: Ubiquitin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:13 2008'' | |||
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Revision as of 20:20, 2 May 2008
Crystal Structure of the mammalian 20S proteasome at 2.75 A resolution
OverviewOverview
The 20S proteasome is the catalytic portion of the 26S proteasome. Constitutively expressed mammalian 20S proteasomes have three active subunits, beta 1, beta 2, and beta 5, which are replaced in the immunoproteasome by interferon-gamma-inducible subunits beta 1i, beta 2i, and beta 5i, respectively. Here we determined the crystal structure of the bovine 20S proteasome at 2.75 A resolution. The structures of alpha 2, beta 1, beta 5, beta 6, and beta 7 subunits of the bovine enzyme were different from the yeast enzyme but enabled the bovine proteasome to accommodate either the constitutive or the inducible subunits. A novel N-terminal nucleophile hydrolase activity was proposed for the beta 7 subunit. We also determined the site of the nuclear localization signals in the molecule. A model of the immunoproteasome was predicted from this constitutive structure.
About this StructureAbout this Structure
1IRU is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the mammalian 20S proteasome at 2.75 A resolution., Unno M, Mizushima T, Morimoto Y, Tomisugi Y, Tanaka K, Yasuoka N, Tsukihara T, Structure. 2002 May;10(5):609-18. PMID:12015144 Page seeded by OCA on Fri May 2 20:20:13 2008