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'''Crystal Structure of Co-type nitrile hydratase from Pseudonocardia thermophila''' | '''Crystal Structure of Co-type nitrile hydratase from Pseudonocardia thermophila''' | ||
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[[Category: Miyanaga, A.]] | [[Category: Miyanaga, A.]] | ||
[[Category: Wakagi, T.]] | [[Category: Wakagi, T.]] | ||
[[Category: | [[Category: Cysteine-sulfenic acid]] | ||
[[Category: | [[Category: Cysteine-sulfinic acid]] | ||
[[Category: | [[Category: Hydration]] | ||
[[Category: | [[Category: Nitrile]] | ||
[[Category: | [[Category: Non-corrin cobalt]] | ||
[[Category: | [[Category: Post-translational modification]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:19:18 2008'' | |||
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Revision as of 20:19, 2 May 2008
Crystal Structure of Co-type nitrile hydratase from Pseudonocardia thermophila
OverviewOverview
The crystal structure of cobalt-containing nitrile hydratase from Pseudonocardia thermophila JCM 3095 at 1.8 A resolution revealed the structure of the noncorrin cobalt at the catalytic center. Two cysteine residues (alphaCys(111) and alphaCys(113)) coordinated to the cobalt were posttranslationally modified to cysteine-sulfinic acid and to cysteine-sulfenic acid, respectively, like in iron-containing nitrile hydratase. A tryptophan residue (betaTrp(72)), which may be involved in substrate binding, replaced the tyrosine residue of iron-containing nitrile hydratase. The difference seems to be responsible for the preference for aromatic nitriles rather than aliphatic ones of cobalt-containing nitrile hydratase.
About this StructureAbout this Structure
1IRE is a Protein complex structure of sequences from Pseudonocardia thermophila. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of cobalt-containing nitrile hydratase., Miyanaga A, Fushinobu S, Ito K, Wakagi T, Biochem Biophys Res Commun. 2001 Nov 16;288(5):1169-74. PMID:11700034 Page seeded by OCA on Fri May 2 20:19:18 2008