4fcp: Difference between revisions
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==Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization== | ==Targetting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization== | ||
<StructureSection load='4fcp' size='340' side='right' caption='[[4fcp]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4fcp' size='340' side='right'caption='[[4fcp]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fcp]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4fcp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FCP FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42C:N,N-DIMETHYL-7H-PURIN-6-AMINE'>42C</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fcp OCA], [https://pdbe.org/4fcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fcp RCSB], [https://www.ebi.ac.uk/pdbsum/4fcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fcp ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Heat Shock | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Brough | [[Category: Large Structures]] | ||
[[Category: Browne | [[Category: Brough P]] | ||
[[Category: Davies | [[Category: Browne H]] | ||
[[Category: Davies | [[Category: Davies B]] | ||
[[Category: Drysdale | [[Category: Davies NGM]] | ||
[[Category: Foloppe | [[Category: Drysdale M]] | ||
[[Category: Geoffrey | [[Category: Foloppe N]] | ||
[[Category: Gibbons | [[Category: Geoffrey S]] | ||
[[Category: Hart | [[Category: Gibbons B]] | ||
[[Category: Jensen | [[Category: Hart T]] | ||
[[Category: Mansell | [[Category: Jensen MR]] | ||
[[Category: Massey | [[Category: Mansell H]] | ||
[[Category: Matassova | [[Category: Massey A]] | ||
[[Category: Moore | [[Category: Matassova N]] | ||
[[Category: Murray | [[Category: Moore JD]] | ||
[[Category: Pratt | [[Category: Murray J]] | ||
[[Category: Ray | [[Category: Pratt R]] | ||
[[Category: Roughley | [[Category: Ray S]] | ||
[[Category: Schoepfer | [[Category: Roughley SD]] | ||
[[Category: Scriven | [[Category: Schoepfer J]] | ||
[[Category: Simmonite | [[Category: Scriven K]] | ||
[[Category: Stokes | [[Category: Simmonite H]] | ||
[[Category: Surgenor | [[Category: Stokes S]] | ||
[[Category: Webb | [[Category: Surgenor A]] | ||
[[Category: Wright | [[Category: Webb P]] | ||
[[Category: Wright L]] | |||