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==Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-bombesin in space group I222== | ==Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-bombesin in space group I222== | ||
<StructureSection load='4ezu' size='340' side='right' caption='[[4ezu]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4ezu' size='340' side='right'caption='[[4ezu]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ezu]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ezu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombina_maxima Bombina maxima] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZU FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ezu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezu OCA], [https://pdbe.org/4ezu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ezu RCSB], [https://www.ebi.ac.uk/pdbsum/4ezu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezu ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] | ||
==See Also== | |||
*[[Heat Shock Protein structures|Heat Shock Protein structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bombina maxima]] | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Straeter N]] | ||
[[Category: | [[Category: Zahn M]] | ||
Revision as of 07:24, 7 October 2022
Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-bombesin in space group I222Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-bombesin in space group I222
Structural highlights
FunctionDNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] See Also |
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