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==Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate== | ==Crystal structure of mouse thymidylate sythase in ternary complex with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate and the cofactor product, dihydrofolate== | ||
<StructureSection load='4ez8' size='340' side='right' caption='[[4ez8]], [[Resolution|resolution]] 1.17Å' scene=''> | <StructureSection load='4ez8' size='340' side='right'caption='[[4ez8]], [[Resolution|resolution]] 1.17Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ez8]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ez8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZ8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOH:2-DEOXY-N-HYDROXYCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>NOH</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ez8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ez8 OCA], [https://pdbe.org/4ez8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ez8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ez8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ez8 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity). | ||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Banaszak | [[Category: Banaszak K]] | ||
[[Category: Dowiercial | [[Category: Dowiercial A]] | ||
[[Category: Gorecka | [[Category: Gorecka K]] | ||
[[Category: Jarmula | [[Category: Jarmula A]] | ||
[[Category: Kierdaszuk | [[Category: Kierdaszuk B]] | ||
[[Category: Rode | [[Category: Rode W]] | ||
[[Category: Rypniewski | [[Category: Rypniewski W]] | ||
[[Category: Wilk | [[Category: Wilk P]] | ||