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==Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)==
==Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)==
<StructureSection load='4evb' size='340' side='right' caption='[[4evb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4evb' size='340' side='right'caption='[[4evb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4evb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EVB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4evb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ta8|3ta8]], [[3t9j|3t9j]], [[4evc|4evc]], [[4evd|4evd]], [[4eve|4eve]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4evb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evb OCA], [https://pdbe.org/4evb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4evb RCSB], [https://www.ebi.ac.uk/pdbsum/4evb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4evb ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">napA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4evb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evb OCA], [http://pdbe.org/4evb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4evb RCSB], [http://www.ebi.ac.uk/pdbsum/4evb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4evb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G1UIZ3_HELPX G1UIZ3_HELPX]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43504]]
[[Category: Helicobacter pylori]]
[[Category: Akao, N]]
[[Category: Large Structures]]
[[Category: Fujii, S]]
[[Category: Akao N]]
[[Category: Tsuruta, O]]
[[Category: Fujii S]]
[[Category: Yokoyama, H]]
[[Category: Tsuruta O]]
[[Category: Dodecamer]]
[[Category: Yokoyama H]]
[[Category: Four-helix bundle]]
[[Category: Metal transport]]

Revision as of 07:18, 7 October 2022

Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM)

Structural highlights

4evb is a 1 chain structure with sequence from Helicobacter pylori. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G1UIZ3_HELPX

Publication Abstract from PubMed

Helicobacter pylori neutrophil-activating protein (HP-NAP) is a Dps-like iron storage protein forming a dodecameric shell, and promotes adhesion of neutrophils to endothelial cells. The crystal structure of HP-NAP in a Zn(2+)- or Cd(2+)-bound form reveals the binding of two zinc or two cadmium ions and their bridged water molecule at the ferroxidase center (FOC). The two zinc ions are coordinated in a tetrahedral manner to the conserved residues among HP-NAP and Dps proteins. The two cadmium ions are coordinated in a trigonal-bipyramidal and distorted octahedral manner. In both structures, the second ion is more weakly coordinated than the first. Another zinc ion is found inside of the negatively-charged threefold-related pore, which is suitable for metal ions to pass through.

Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form.,Yokoyama H, Tsuruta O, Akao N, Fujii S Biochem Biophys Res Commun. 2012 Jun 15;422(4):745-50. Epub 2012 May 19. PMID:22618234[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Yokoyama H, Tsuruta O, Akao N, Fujii S. Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form. Biochem Biophys Res Commun. 2012 Jun 15;422(4):745-50. Epub 2012 May 19. PMID:22618234 doi:10.1016/j.bbrc.2012.05.073

4evb, resolution 2.50Å

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