3o6a: Difference between revisions

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 ==F144Y/F258Y Double Mutant of Exo-beta-1,3-glucanase from Candida albicans at 2 A==
-<StructureSection load='3o6a' size='340' side='right' caption='[[3o6a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='3o6a' size='340' side='right'caption='[[3o6a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3o6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O6A FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3o6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O6A FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cz1|1cz1]], [[2pf0|2pf0]], [[3n9k|3n9k]], [[2pbo|2pbo]], [[1eqc|1eqc]], [[2pc8|2pc8]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6a OCA], [https://pdbe.org/3o6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o6a RCSB], [https://www.ebi.ac.uk/pdbsum/3o6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6a ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XOG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucan_1,3-beta-glucosidase Glucan 1,3-beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.58 3.2.1.58] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6a OCA], [http://pdbe.org/3o6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o6a RCSB], [http://www.ebi.ac.uk/pdbsum/3o6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6a ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/EXG_CANAL EXG_CANAL]] Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.
+[https://www.uniprot.org/uniprot/EXG1_CANAL EXG1_CANAL] Major glucan 1,3-beta-glucosidase required for cell wall integrity. Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Can also function biosynthetically as a transglycosylase. Functions to deliver glucan from the cell to the extracellular matrix. Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation. Involved in cell-substrate and cell-cell adhesion. Adhesion to host-cell surfaces is the first critical step during mucosal infection. XOG1 is target of human antimicrobial peptide LL-37 for inhibition of cell adhesion.<ref>PMID:21713010</ref> <ref>PMID:22876186</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 29: @@
 ==See Also==
-*[[Beta-glucosidase|Beta-glucosidase]]
+*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
-*[[Glucanase|Glucanase]]
+*[[Glucanase 3D structures|Glucanase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Glucan 1,3-beta-glucosidase]]
+[[Category: Candida albicans]]
-[[Category: Cutfield, J F]]
+[[Category: Large Structures]]
-[[Category: Cutfield, S M]]
+[[Category: Cutfield JF]]
-[[Category: Nakatani, Y]]
+[[Category: Cutfield SM]]
-[[Category: Cell wall]]
+[[Category: Nakatani Y]]
-[[Category: Glycoside hydrolase]]
-[[Category: Gycoside hydrolase family 5]]
-[[Category: Hydrolase]]
-[[Category: Secreted]]
-[[Category: Tim barrel]]