4ej4: Difference between revisions

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 ==Structure of the delta opioid receptor bound to naltrindole==
-<StructureSection load='4ej4' size='340' side='right' caption='[[4ej4]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+<StructureSection load='4ej4' size='340' side='right'caption='[[4ej4]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ej4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EJ4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ej4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJ4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EJ4:(4BS,8R,8AS,14BR)-7-(CYCLOPROPYLMETHYL)-5,6,7,8,14,14B-HEXAHYDRO-4,8-METHANO[1]BENZOFURO[2,3-A]PYRIDO[4,3-B]CARBAZOLE-1,8A(9H)-DIOL'>EJ4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJ4:(4BS,8R,8AS,14BR)-7-(CYCLOPROPYLMETHYL)-5,6,7,8,14,14B-HEXAHYDRO-4,8-METHANO[1]BENZOFURO[2,3-A]PYRIDO[4,3-B]CARBAZOLE-1,8A(9H)-DIOL'>EJ4</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Oprd1, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ej4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej4 OCA], [https://pdbe.org/4ej4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ej4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ej4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ej4 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ej4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ej4 OCA], [http://pdbe.org/4ej4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ej4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ej4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ej4 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/OPRD_MOUSE OPRD_MOUSE]] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:10677041</ref> <ref>PMID:1334555</ref> <ref>PMID:1335167</ref>
+[[https://www.uniprot.org/uniprot/OPRD_MOUSE OPRD_MOUSE]] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:10677041</ref> <ref>PMID:1334555</ref> <ref>PMID:1335167</ref> [[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4]] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 ==See Also==
-*[[Delta opioid receptor|Delta opioid receptor]]
 *[[Lysozyme 3D structures|Lysozyme 3D structures]]
+*[[Opioid receptor|Opioid receptor]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Escherichia virus T4]]
-[[Category: Lysozyme]]
+[[Category: Large Structures]]
-[[Category: Granier, S]]
+[[Category: Mus musculus]]
-[[Category: Kobilka, B K]]
+[[Category: Granier S]]
-[[Category: Kobilka, T S]]
+[[Category: Kobilka BK]]
-[[Category: Kruse, A C]]
+[[Category: Kobilka TS]]
-[[Category: Manglik, A]]
+[[Category: Kruse AC]]
-[[Category: Thian, F S]]
+[[Category: Manglik A]]
-[[Category: Weis, W I]]
+[[Category: Thian FS]]
-[[Category: Transmembrane receptor]]
+[[Category: Weis WI]]
-[[Category: G-protein coupled receptor]]
-[[Category: Hydrolase-antagonist complex]]
-[[Category: Opioid receptor]]
-[[Category: Signaling protein]]