4efb: Difference between revisions

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<StructureSection load='4efb' size='340' side='right'caption='[[4efb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4efb' size='340' side='right'caption='[[4efb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4efb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4efb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0OW:4-AMINO-2-(CYCLOPENTYLOXY)-6-{[(1R,2S)-2-HYDROXYCYCLOPENTYL]OXY}PYRIMIDINE-5-CARBOXAMIDE'>0OW</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0OW:4-AMINO-2-(CYCLOPENTYLOXY)-6-{[(1R,2S)-2-HYDROXYCYCLOPENTYL]OXY}PYRIMIDINE-5-CARBOXAMIDE'>0OW</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eeq|4eeq]], [[4efe|4efe]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efb OCA], [https://pdbe.org/4efb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efb RCSB], [https://www.ebi.ac.uk/pdbsum/4efb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efb OCA], [http://pdbe.org/4efb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4efb RCSB], [http://www.ebi.ac.uk/pdbsum/4efb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4efb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).  
[[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).


==See Also==
==See Also==
*[[DNA ligase|DNA ligase]]
*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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__TOC__
</StructureSection>
</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Charifson, P]]
[[Category: Charifson P]]
[[Category: Wang, T]]
[[Category: Wang T]]
[[Category: Wei, Y]]
[[Category: Wei Y]]
[[Category: Xu, W]]
[[Category: Xu W]]
[[Category: Adenylation]]
[[Category: Alpha-beta protein]]
[[Category: Enzyme]]
[[Category: Ligase-ligase inhibitor complex]]

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