4e74: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
==Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A== | ==Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A== | ||
<StructureSection load='4e74' size='340' side='right' caption='[[4e74]], [[Resolution|resolution]] 1.58Å' scene=''> | <StructureSection load='4e74' size='340' side='right'caption='[[4e74]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4e74]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4e74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E74 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e74 OCA], [https://pdbe.org/4e74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e74 RCSB], [https://www.ebi.ac.uk/pdbsum/4e74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e74 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/PLXA4_HUMAN PLXA4_HUMAN]] Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). | ||
==See Also== | ==See Also== | ||
Line 15: | Line 14: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Dong | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Dong A]] | ||
[[Category: Guan | [[Category: Edwards AM]] | ||
[[Category: Park | [[Category: Guan X]] | ||
[[Category: Park H]] | |||
[[Category: Tempel | [[Category: Tempel W]] | ||
[[Category: Tong | [[Category: Tong Y]] | ||
[[Category: Wang | [[Category: Wang H]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||