4do8: Difference between revisions

<table><tr><td colspan='2'>[[4do8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DO8 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4do8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4do8 OCA], [https://pdbe.org/4do8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4do8 RCSB], [https://www.ebi.ac.uk/pdbsum/4do8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4do8 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/3SIM1_DENAN 3SIM1_DENAN]] Shows a non-competitive interaction with adrenergic and muscarinic receptors. Binds to alpha-2b (ADRA2B) (IC(50)=2.3 nM), alpha-1a (ADRA1A), alpha-1b (ADRA1B), and alpha-2c (ADRA2C) adrenergic receptors. Reversibly binds to M1 (CHRM1) muscarinic acetylcholine receptors, probably by interacting with the orthosteric site (PubMed:7778123, PubMed:12488533, PubMed:24793485). Also reveals a slightly weaker effect at M3 (CHRM3) and M4 (CHRM4) receptors (PubMed:7778123, PubMed:12488533, PubMed:24793485). The order of potency is ADRA2B>>CHRM1>ADRA1A>ADRA1B>ADRA2C/CHRM4 (PubMed:24793485).<ref>PMID:12488533</ref> <ref>PMID:21557730</ref> <ref>PMID:24793485</ref> <ref>PMID:7778123</ref>

[[Category: Fruchart-Gaillard C]]

[[Category: Mournier G]]

[[Category: Servent D]]

[[Category: Stura EA]]

[[Category: Vera L]]