4dmx: Difference between revisions

<StructureSection load='4dmx' size='340' side='right'caption='[[4dmx]], [[Resolution|resolution]] 1.70&Aring;' scene=''>

<table><tr><td colspan='2'>[[4dmx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DMX FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LB:(1R,2R)-N-(1-CYANOCYCLOPROPYL)-2-{[4-(4-FLUOROPHENYL)PIPERAZIN-1-YL]CARBONYL}CYCLOHEXANECARBOXAMIDE'>0LB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dmx OCA], [https://pdbe.org/4dmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dmx RCSB], [https://www.ebi.ac.uk/pdbsum/4dmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dmx ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>  

[[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Beeley H]]

[[Category: Bowyer J]]

[[Category: Cook CR]]

[[Category: Crawford JJ]]

[[Category: Dossetter AG]]

[[Category: Finlayson JE]]

[[Category: Gutierrez PM]]

[[Category: Heron NM]]

[[Category: Heyes C]]

[[Category: Highton AJ]]

[[Category: Hudson JA]]

[[Category: Jestel A]]

[[Category: Kenny PW]]

[[Category: Krapp S]]

[[Category: MacFaul PA]]

[[Category: Martin S]]

[[Category: McGuire TM]]

[[Category: Morley AD]]

[[Category: Morris JJ]]

[[Category: Page KM]]

[[Category: Rosenbrier Ribeiro L]]

[[Category: Sawney H]]

[[Category: Smith C]]

[[Category: Steinbacher S]]

[[Category: Vickers M]]