4dky: Difference between revisions

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 ==Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Rv]==
-<StructureSection load='4dky' size='340' side='right' caption='[[4dky]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
+<StructureSection load='4dky' size='340' side='right'caption='[[4dky]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4dky]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DKY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4dky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKY FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c4i|3c4i]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dky OCA], [https://pdbe.org/4dky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dky RCSB], [https://www.ebi.ac.uk/pdbsum/4dky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dky ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hlp, hup, hupB, lbp21, MT3064, MTCY349.01, Rv2986c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dky OCA], [http://pdbe.org/4dky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dky RCSB], [http://www.ebi.ac.uk/pdbsum/4dky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dky ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DBH_MYCTU DBH_MYCTU]] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds DNA non-specifically. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against HIST1H1D cross-reacting with DBH epitopes. In CD, target of a strong IgA response.<ref>PMID:10569769</ref> <ref>PMID:10645441</ref>
+[[https://www.uniprot.org/uniprot/DBH_MYCTU DBH_MYCTU]] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds DNA non-specifically. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against HIST1H1D cross-reacting with DBH epitopes. In CD, target of a strong IgA response.<ref>PMID:10569769</ref> <ref>PMID:10645441</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Bhowmick, T]]
+[[Category: Large Structures]]
-[[Category: Ghosh, S]]
+[[Category: Mycobacterium tuberculosis]]
-[[Category: Nagaraja, V]]
+[[Category: Bhowmick T]]
-[[Category: Ramagopal, U A]]
+[[Category: Ghosh S]]
-[[Category: Ramakumar, S]]
+[[Category: Nagaraja V]]
-[[Category: Dna binding protein]]
+[[Category: Ramagopal UA]]
-[[Category: Gene regulation]]
+[[Category: Ramakumar S]]
-[[Category: Genome compaction]]
-[[Category: Histone-like]]
-[[Category: Hu]]
-[[Category: Hu-ihf fold]]
-[[Category: Nucleoid architecture]]
-[[Category: Nucleoid associated protein]]