7usc: Difference between revisions

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-'''Unreleased structure'''
-The entry 7usc is ON HOLD  until Paper Publication
+==Cryo-EM structure of WAVE Regulatory Complex==
+<StructureSection load='7usc' size='340' side='right'caption='[[7usc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7usc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USC FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7usc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7usc OCA], [https://pdbe.org/7usc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7usc RCSB], [https://www.ebi.ac.uk/pdbsum/7usc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7usc ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Angelman syndrome.
+== Function ==
+[[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen B]]
+[[Category: Chowdhury S]]
+[[Category: Ding B]]
+[[Category: Yang S]]