1ieb: Difference between revisions

Revision as of 19:54, 2 May 2008

HISTOCOMPATIBILITY ANTIGEN

OverviewOverview

The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E(k), occupied by either of two antigenic peptides were determined. They reveal the structural basis for the I-E(k) peptide binding motif and suggest general principles for additional alleles. A buried cluster of acidic amino acids in the binding groove predicted to be conserved among all murine I-E and human DR MHC class II molecules suggests how pH may influence MHC binding or exchange of peptides. These structures also complement mutational studies on the importance of individual peptide residues to T cell receptor recognition.

About this StructureAbout this Structure

1IEB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structures of an MHC class II molecule with covalently bound single peptides., Fremont DH, Hendrickson WA, Marrack P, Kappler J, Science. 1996 May 17;272(5264):1001-4. PMID:8638119 Page seeded by OCA on Fri May 2 19:54:22 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1ieb.gif|left|200px]]
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-}}
 '''HISTOCOMPATIBILITY ANTIGEN'''
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 [[Category: Kappler, J.]]
 [[Category: Marrack, P.]]
-[[Category: histocompatibility antigen]]
+[[Category: Histocompatibility antigen]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:54:22 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:18:35 2008''