4d09: Difference between revisions

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<StructureSection load='4d09' size='340' side='right'caption='[[4d09]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4d09' size='340' side='right'caption='[[4d09]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d09]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D09 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d09]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D09 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=788:N-BENZYL-4-METHYL-1-PHENYL[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE-8-CARBOXAMIDE'>788</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d08|4d08]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d09 OCA], [https://pdbe.org/4d09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d09 RCSB], [https://www.ebi.ac.uk/pdbsum/4d09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d09 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d09 OCA], [http://pdbe.org/4d09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d09 RCSB], [http://www.ebi.ac.uk/pdbsum/4d09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d09 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN]] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
[[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN]] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Andres, J I]]
[[Category: Andres JI]]
[[Category: Buijnsters, P]]
[[Category: Buijnsters P]]
[[Category: DeAngelis, M]]
[[Category: DeAngelis M]]
[[Category: Langlois, X]]
[[Category: Langlois X]]
[[Category: Rombouts, F]]
[[Category: Rombouts F]]
[[Category: Sanderson, W]]
[[Category: Sanderson W]]
[[Category: Trabanco, A]]
[[Category: Trabanco A]]
[[Category: Tresadern, G]]
[[Category: Tresadern G]]
[[Category: VanHoof, G]]
[[Category: VanHoof G]]
[[Category: VanRoosbroeck, Y]]
[[Category: VanRoosbroeck Y]]
[[Category: Animal]]
[[Category: Cyclic nucleotide phosphodiesterase]]
[[Category: Disease model]]
[[Category: Drug evaluation]]
[[Category: Hydrolase]]
[[Category: Phosphodiesterase 2 inhibitor]]
[[Category: Phosphodiesterase inhibitor]]
[[Category: Preclinical]]
[[Category: Protein binding]]
[[Category: Structure-activity relationship]]
[[Category: Type 2]]
[[Category: Type 4]]

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