4cl1: Difference between revisions
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==The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors== | ==The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors== | ||
<StructureSection load='4cl1' size='340' side='right' caption='[[4cl1]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='4cl1' size='340' side='right'caption='[[4cl1]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cl1]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4cl1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_(isolate_H77) Hepatitis C virus (isolate H77)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CL1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cl1 OCA], [https://pdbe.org/4cl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4cl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cl1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/K4KA16_9HEPC K4KA16_9HEPC]] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Angell | [[Category: Large Structures]] | ||
[[Category: Garnett | [[Category: Angell R]] | ||
[[Category: Hedgethorne | [[Category: Garnett JA]] | ||
[[Category: Lambert | [[Category: Hedgethorne K]] | ||
[[Category: Langley | [[Category: Lambert SM]] | ||
[[Category: Matthews | [[Category: Langley DR]] | ||
[[Category: Meanwell | [[Category: Matthews SJ]] | ||
[[Category: Meanwell NA]] |