Ankyrin repeat domain-containing protein: Difference between revisions
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The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>. | The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>. | ||
== 3D structures of ankyrin repeat domain-containing protein == | |||
[[Ankyrin repeat domain-containing protein 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br /> | [[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br /> | ||
[[6jd6]] - AtARDCP EMB56 + ARDCP<br /> | [[6jd6]] - AtARDCP EMB56 + ARDCP<br /> | ||
[[7ubz]] – ARDCP residues 1-230 + lipase effector – ''Enterobacter cloacae''<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:06, 11 September 2022
FunctionAnkyrin repeat domain-containing protein (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain[1]. DiseaseMutations in ARDCP 3 manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities[2]. Structural highlightsThe 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues and residues [1]. . 3D structures of ankyrin repeat domain-containing proteinAnkyrin repeat domain-containing protein 3D structures
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3D structures of ankyrin repeat domain-containing protein3D structures of ankyrin repeat domain-containing protein
4nl9 - hARDCP 3 SAM domain + hARDCP 14 SAM domain - human
5ybj - hARDCP 15 residues 1080-1329
5ybu - hARDCP 15 residues 1080-1329 + KIF21A peptide
4hbd - hARDCP 25 residues 578-832
6tmd - hARDCP 25 residues 583-832 (mutant)
5ybv - hARDCP 25 residues 578-832 + KIF21A peptide
4cym - hARDCP 27 residues 450-640 + RAB32
4cz2 - hARDCP 27 residues 450-640 + RAB32 + GPPCP
4b93 - hARDCP 27 residues 659-921 + VAMP7
5wni - mARDCP 3 residues 1-342 - mouse
5wnk - mARDCP 3 residues 1-342 (mutant)
5wnj, 5wnm - mARDCP 3 residues 1-342 (mutant) + cancer drug
5wnl - mARDCP 3 residues 1-342 (mutant) + staurosporine
6nxf - mARDCP 31 C-terminal + REC114
6tlh - mARDCP 47 residues 524-773
5eid, 4tum - AtARDCP 2 residues 211-342 - Arabidopis thaliana
6jd6 - AtARDCP EMB56 + ARDCP
7ubz – ARDCP residues 1-230 + lipase effector – Enterobacter cloacae
ReferencesReferences
- ↑ 1.0 1.1 Guo Q, Liao S, Zhu Z, Li Y, Li F, Xu C. Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. J Biol Chem. 2017 Nov 28. pii: M117.817494. doi: 10.1074/jbc.M117.817494. PMID:29183992 doi:http://dx.doi.org/10.1074/jbc.M117.817494
- ↑ Huang CS, Oberbeck N, Hsiao YC, Liu P, Johnson AR, Dixit VM, Hymowitz SG. Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure. 2018 May 1;26(5):767-777.e5. doi: 10.1016/j.str.2018.04.002. Epub 2018, Apr 26. PMID:29706531 doi:http://dx.doi.org/10.1016/j.str.2018.04.002