7f80: Difference between revisions
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==Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD== | ==Co-crystal structure of Inhibitor compound MA-211 in complex with human PPARdelta LBD== | ||
<StructureSection load='7f80' size='340' side='right'caption='[[7f80]]' scene=''> | <StructureSection load='7f80' size='340' side='right'caption='[[7f80]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F80 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7f80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F80 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f80 OCA], [https://pdbe.org/7f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f80 RCSB], [https://www.ebi.ac.uk/pdbsum/7f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f80 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KF:(3R)-3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethyl)phenyl]imidazol-1-yl]methyl]phenoxy]hexanoic+acid'>1KF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f80 OCA], [https://pdbe.org/7f80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f80 RCSB], [https://www.ebi.ac.uk/pdbsum/7f80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f80 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Krishnamurthy N]] | [[Category: Krishnamurthy N]] | ||