7vv5: Difference between revisions

Revision as of 08:33, 8 September 2022

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1

Structural highlights

7vv5 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.^[1] ^[2]

References

↑ Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114
↑ Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

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OCA

[1] Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114

[2] Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

[1]

[2]

@@ Line 1: / Line 1: @@
-====
+==Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1==
-<StructureSection load='7vv5' size='340' side='right'caption='[[7vv5]]' scene=''>
+<StructureSection load='7vv5' size='340' side='right'caption='[[7vv5]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7vv5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VV5 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vv5 OCA], [https://pdbe.org/7vv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vv5 RCSB], [https://www.ebi.ac.uk/pdbsum/7vv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vv5 ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6IB:2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine'>6IB</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vv5 OCA], [https://pdbe.org/7vv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vv5 RCSB], [https://www.ebi.ac.uk/pdbsum/7vv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vv5 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
+==See Also==
+*[[Transducin 3D structures|Transducin 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Li Y]]
+[[Category: Yang F]]

7vv5: Difference between revisions

Revision as of 08:33, 8 September 2022

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1

Structural highlights

Function

See Also

References

Contents

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7vv5: Difference between revisions

Revision as of 08:33, 8 September 2022

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1

Structural highlights

Function

See Also

References

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