7e20: Difference between revisions

Revision as of 08:21, 8 September 2022

Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 stateCryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state

Structural highlights

7e20 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[AT1B1_HUMAN] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520).^[1] ^[2] Involved in cell adhesion and establishing epithelial cell polarity.^[3]

References

↑ Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009 Sep 15;48(36):8684-91. doi: 10.1021/bi900868e. PMID:19694409 doi:http://dx.doi.org/10.1021/bi900868e
↑ Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y. Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6. J Immunol. 2021 Jun 1;206(11):2668-2681. doi: 10.4049/jimmunol.2001262. Epub 2021, May 19. PMID:34011520 doi:http://dx.doi.org/10.4049/jimmunol.2001262
↑ Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009 Sep 15;48(36):8684-91. doi: 10.1021/bi900868e. PMID:19694409 doi:http://dx.doi.org/10.1021/bi900868e

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OCA

[1] Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009 Sep 15;48(36):8684-91. doi: 10.1021/bi900868e. PMID:19694409 doi:http://dx.doi.org/10.1021/bi900868e

[2] Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y. Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6. J Immunol. 2021 Jun 1;206(11):2668-2681. doi: 10.4049/jimmunol.2001262. Epub 2021, May 19. PMID:34011520 doi:http://dx.doi.org/10.4049/jimmunol.2001262

[3] Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009 Sep 15;48(36):8684-91. doi: 10.1021/bi900868e. PMID:19694409 doi:http://dx.doi.org/10.1021/bi900868e

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-====
+==Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state==
-<StructureSection load='7e20' size='340' side='right'caption='[[7e20]]' scene=''>
+<StructureSection load='7e20' size='340' side='right'caption='[[7e20]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7e20]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E20 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e20 OCA], [https://pdbe.org/7e20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e20 RCSB], [https://www.ebi.ac.uk/pdbsum/7e20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e20 ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e20 OCA], [https://pdbe.org/7e20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e20 RCSB], [https://www.ebi.ac.uk/pdbsum/7e20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e20 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[[https://www.uniprot.org/uniprot/AT1B1_HUMAN AT1B1_HUMAN]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520).<ref>PMID:19694409</ref> <ref>PMID:34011520</ref>   Involved in cell adhesion and establishing epithelial cell polarity.<ref>PMID:19694409</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Z-disk]]
+[[Category: Chi XM]]
+[[Category: Guo YY]]
+[[Category: Huang BD]]
+[[Category: Wu LS]]
+[[Category: Yan RH]]
+[[Category: Ye FF]]
+[[Category: Zhang YY]]
+[[Category: Zhou Q]]

7e20: Difference between revisions

Revision as of 08:21, 8 September 2022

Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 stateCryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state

Structural highlights

Function

References

Contents

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7e20: Difference between revisions

Revision as of 08:21, 8 September 2022

Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 stateCryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state

Structural highlights

Function

References

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