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==== | ==Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D== | ||
<StructureSection load='7fi9' size='340' side='right'caption='[[7fi9]]' scene=''> | <StructureSection load='7fi9' size='340' side='right'caption='[[7fi9]], [[Resolution|resolution]] 2.16Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7fi9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FI9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fi9 OCA], [https://pdbe.org/7fi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fi9 RCSB], [https://www.ebi.ac.uk/pdbsum/7fi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fi9 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fi9 OCA], [https://pdbe.org/7fi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fi9 RCSB], [https://www.ebi.ac.uk/pdbsum/7fi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fi9 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN]] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cai W]] | ||
[[Category: Li Y]] | |||
[[Category: Liu J]] | |||
[[Category: Peng S]] | |||
[[Category: Tian Y]] | |||
[[Category: Xu T]] | |||
Revision as of 22:20, 7 September 2022
Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2DCrystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D
Structural highlights
Function[NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. |
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