1i7x: Difference between revisions

Revision as of 19:41, 2 May 2008

BETA-CATENIN/E-CADHERIN COMPLEX

OverviewOverview

As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.

About this StructureAbout this Structure

1I7X is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin., Huber AH, Weis WI, Cell. 2001 May 4;105(3):391-402. PMID:11348595 Page seeded by OCA on Fri May 2 19:41:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1i7x.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1i7x |SIZE=350|CAPTION= <scene name='initialview01'>1i7x</scene>, resolution 3.00&Aring;
+The line below this paragraph, containing "STRUCTURE_1i7x", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= CATNB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+-->
-|DOMAIN=
+{{STRUCTURE_1i7x|  PDB=1i7x  |  SCENE=  }}
-|RELATEDENTRY=[[1i7w|1I7W]], [[2bct|2BCT]], [[3bct|3BCT]], [[1g3j|1G3J]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7x OCA], [http://www.ebi.ac.uk/pdbsum/1i7x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i7x RCSB]</span>
-}}
 '''BETA-CATENIN/E-CADHERIN COMPLEX'''
@@ Line 27: / Line 24: @@
 [[Category: Huber, A H.]]
 [[Category: Weis, W I.]]
-[[Category: armadillo repeat]]
+[[Category: Armadillo repeat]]
-[[Category: beta-catenin]]
+[[Category: Beta-catenin]]
-[[Category: cell adhesion]]
+[[Category: Cell adhesion]]
-[[Category: e-cadherin]]
+[[Category: E-cadherin]]
-[[Category: extended interface]]
+[[Category: Extended interface]]
-[[Category: protein-protein complex]]
+[[Category: Protein-protein complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:41:10 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:15:51 2008''