4c7h: Difference between revisions

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<StructureSection load='4c7h' size='340' side='right'caption='[[4c7h]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='4c7h' size='340' side='right'caption='[[4c7h]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C7H FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C7H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EN5:N-(10-AMINODECANOYL)-L-SERYL-N-(2-CYCLOHEXYLETHYL)-L-LYSINAMIDE'>EN5</scene>, <scene name='pdbligand=ENF:N-{(5E)-10-[(9E)-TETRADEC-9-ENOYLAMINO]DEC-5-ENOYL}-L-SERYL-N-(2-CYCLOHEXYLETHYL)-L-LYSINAMIDE'>ENF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EN5:N-(10-AMINODECANOYL)-L-SERYL-N-(2-CYCLOHEXYLETHYL)-L-LYSINAMIDE'>EN5</scene>, <scene name='pdbligand=ENF:N-{(5E)-10-[(9E)-TETRADEC-9-ENOYLAMINO]DEC-5-ENOYL}-L-SERYL-N-(2-CYCLOHEXYLETHYL)-L-LYSINAMIDE'>ENF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c68|4c68]], [[4c7i|4c7i]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7h OCA], [https://pdbe.org/4c7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c7h RCSB], [https://www.ebi.ac.uk/pdbsum/4c7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c7h ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7h OCA], [http://pdbe.org/4c7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c7h RCSB], [http://www.ebi.ac.uk/pdbsum/4c7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c7h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).  
[[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub-micromolar peptidomimetic inhibitors of Plasmodium and Leishmania NMTs. High-resolution structures of these inhibitors with Plasmodium and Leishmania NMTs permit a comparative analysis of binding modes, and provide the first crystal structure evidence for a ternary NMT-Coenzyme A/myristoylated peptide product complex.
 
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.,Olaleye TO, Brannigan JA, Roberts SM, Leatherbarrow RJ, Wilkinson AJ, Tate EW Org Biomol Chem. 2014 Sep 18. PMID:25230674<ref>PMID:25230674</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4c7h" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Leima]]
[[Category: Leishmania major]]
[[Category: Brannigan, J A]]
[[Category: Brannigan JA]]
[[Category: Goncalves, V]]
[[Category: Goncalves V]]
[[Category: Leatherbarrow, R J]]
[[Category: Leatherbarrow RJ]]
[[Category: Olaleye, T O]]
[[Category: Olaleye TO]]
[[Category: Roberts, S M]]
[[Category: Roberts SM]]
[[Category: Tate, E W]]
[[Category: Tate EW]]
[[Category: Wilkinson, A J]]
[[Category: Wilkinson AJ]]
[[Category: Myristoylation]]
[[Category: Transferase]]

Revision as of 20:30, 7 September 2022

Leismania major N-myristoyltransferase in complex with a peptidomimetic (-NH2) moleculeLeismania major N-myristoyltransferase in complex with a peptidomimetic (-NH2) molecule

Structural highlights

4c7h is a 1 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).

4c7h, resolution 1.40Å

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OCA
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