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| <StructureSection load='4c40' size='340' side='right'caption='[[4c40]], [[Resolution|resolution]] 2.20Å' scene=''> | | <StructureSection load='4c40' size='340' side='right'caption='[[4c40]], [[Resolution|resolution]] 2.20Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[4c40]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C40 FirstGlance]. <br> | | <table><tr><td colspan='2'>[[4c40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C40 FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw0|4bw0]], [[4c4w|4c4w]]</td></tr> | | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c40 OCA], [https://pdbe.org/4c40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c40 RCSB], [https://www.ebi.ac.uk/pdbsum/4c40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c40 ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c40 OCA], [http://pdbe.org/4c40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c40 RCSB], [http://www.ebi.ac.uk/pdbsum/4c40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c40 ProSAT]</span></td></tr> | |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| L7Ae is a member of a protein family that binds kink-turns (k-turns) in many functional RNA species. We have solved the X-ray crystal structure of the near-consensus sequence Kt-7 of Haloarcula marismortui bound by Archaeoglobus fulgidus L7Ae at 2.3-A resolution. We also present a structure of Kt-7 in the absence of bound protein at 2.2-A resolution. As a result, we can describe a general mode of recognition of k-turn structure by the L7Ae family proteins. The protein makes interactions in the widened major groove on the outer face of the k-turn. Two regions of the protein are involved. One is an alpha-helix that enters the major groove of the NC helix, making both nonspecific backbone interactions and specific interactions with the guanine nucleobases of the conserved G*A pairs. A hydrophobic loop makes close contact with the L1 and L2 bases, and a glutamate side chain hydrogen bonds with L1. Taken together, these interactions are highly selective for the structure of the k-turn and suggest how conformational selection of the folded k-turn occurs.
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| The molecular recognition of kink-turn structure by the L7Ae class of proteins.,Huang L, Lilley DM RNA. 2013 Oct 22. PMID:24149842<ref>PMID:24149842</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 4c40" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| | [[Category: Haloarcula marismortui]] |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Huang, L]] | | [[Category: Huang L]] |
| [[Category: Lilley, D M.J]] | | [[Category: Lilley DMJ]] |
| [[Category: Dna]]
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| [[Category: Kink turn]]
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| [[Category: Rna]]
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