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==== | ==Tetrahymena CST with Polymerase alpha-Primase== | ||
<StructureSection load='7uy7' size='340' side='right'caption='[[7uy7]]' scene=''> | <StructureSection load='7uy7' size='340' side='right'caption='[[7uy7]], [[Resolution|resolution]] 4.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7uy7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UY7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uy7 OCA], [https://pdbe.org/7uy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uy7 RCSB], [https://www.ebi.ac.uk/pdbsum/7uy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uy7 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uy7 OCA], [https://pdbe.org/7uy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uy7 RCSB], [https://www.ebi.ac.uk/pdbsum/7uy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uy7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/TAP19_TETTS TAP19_TETTS]] Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).<ref>PMID:26551074</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Tetrahymena thermophila]] | ||
[[Category: Chan H]] | |||
[[Category: Feigon J]] | |||
[[Category: He Y]] | |||
[[Category: Liu B]] | |||
[[Category: Song H]] | |||
[[Category: Susac L]] | |||
[[Category: Wang Y]] | |||
[[Category: Zhou ZH]] | |||
Revision as of 19:49, 7 September 2022
Tetrahymena CST with Polymerase alpha-PrimaseTetrahymena CST with Polymerase alpha-Primase
Structural highlights
Function[TAP19_TETTS] Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074). The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).[1] References
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