7um3: Difference between revisions

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-'''Unreleased structure'''
-The entry 7um3 is ON HOLD  until Paper Publication
+==Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion==
+<StructureSection load='7um3' size='340' side='right'caption='[[7um3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Zorn, J.A., Lee, P.S., Rajpal, A., Strop, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7um3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UM3 FirstGlance]. <br>
-Description: Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7um3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7um3 OCA], [https://pdbe.org/7um3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7um3 RCSB], [https://www.ebi.ac.uk/pdbsum/7um3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7um3 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Strop, P]]
+== Function ==
-[[Category: Rajpal, A]]
+[[https://www.uniprot.org/uniprot/LAG3_HUMAN LAG3_HUMAN]] Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).[UniProtKB:Q61790]<ref>PMID:20421648</ref> <ref>PMID:7805750</ref> <ref>PMID:8647185</ref>   May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.[UniProtKB:Q61790]
-[[Category: Lee, P.S]]
+== References ==
-[[Category: Zorn, J.A]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Lee PS]]
+[[Category: Rajpal A]]
+[[Category: Strop P]]
+[[Category: Zorn JA]]