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==Backbone 1H, 13C, and 15N Chemical Shift Assignments for cold shock protein, TaCsp==
==Backbone 1H, 13C, and 15N Chemical Shift Assignments for cold shock protein, TaCsp==
<StructureSection load='2mo0' size='340' side='right'caption='[[2mo0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mo0' size='340' side='right'caption='[[2mo0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mo0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MO0 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MO0 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mo1|2mo1]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mo0 OCA], [https://pdbe.org/2mo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mo0 RCSB], [https://www.ebi.ac.uk/pdbsum/2mo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mo0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mo0 OCA], [https://pdbe.org/2mo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mo0 RCSB], [https://www.ebi.ac.uk/pdbsum/2mo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mo0 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The thermophilic bacterium Thermus aquaticus is a well-known source of Taq polymerase. Here, we studied the structure and dynamics of the T. aquaticus cold-shock protein (Ta-Csp) to better understand its thermostability using NMR spectroscopy. We found that Ta-Csp has a five-stranded beta-barrel structure with five salt bridges which are important for more rigid structure and a higher melting temperature (76 degrees C) of Ta-Csp compared to mesophilic and psychrophilic Csps. Microsecond to millisecond time scale exchange processes occur only at the beta1-beta2 surface region of the nucleic acid binding site with an average conformational exchange rate constant of 674s-1. The results imply that thermophilic Ta-Csp has a more rigid structure and may not need high structural flexibility to accommodate nucleic acids upon cold shock compared to its mesophile and psychrophile counterparts.
Structure and flexibility of the thermophilic cold-shock protein of Thermus aquaticus.,Jin B, Jeong KW, Kim Y Biochem Biophys Res Commun. 2014 Aug 4. pii: S0006-291X(14)01377-1. doi:, 10.1016/j.bbrc.2014.07.127. PMID:25101648<ref>PMID:25101648</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mo0" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jeong, K W]]
[[Category: Jeong KW]]
[[Category: Jin, B]]
[[Category: Jin B]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Cold shock protein]]
[[Category: Dna binding protein]]
[[Category: Protein binding]]
[[Category: Protein stability]]
[[Category: Thermus aquaticus]]

Revision as of 13:23, 31 August 2022

Backbone 1H, 13C, and 15N Chemical Shift Assignments for cold shock protein, TaCspBackbone 1H, 13C, and 15N Chemical Shift Assignments for cold shock protein, TaCsp

Structural highlights

Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT
Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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