4b87: Difference between revisions

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<StructureSection load='4b87' size='340' side='right'caption='[[4b87]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
<StructureSection load='4b87' size='340' side='right'caption='[[4b87]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b87]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B87 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b87]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B87 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b87 OCA], [http://pdbe.org/4b87 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b87 RCSB], [http://www.ebi.ac.uk/pdbsum/4b87 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b87 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b87 OCA], [https://pdbe.org/4b87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b87 RCSB], [https://www.ebi.ac.uk/pdbsum/4b87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b87 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN]] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref>   
[[https://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN]] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref>   
== References ==
== References ==
<references/>
<references/>

Revision as of 10:03, 31 August 2022

Crystal structure of human DNA cross-link repair 1ACrystal structure of human DNA cross-link repair 1A

Structural highlights

4b87 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DCR1A_HUMAN] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.[1]

References

  1. Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol. 2004 Dec;24(23):10448-55. PMID:15542852 doi:http://dx.doi.org/24/23/10448

4b87, resolution 2.16Å

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