4b3e: Difference between revisions

<table><tr><td colspan='2'>[[4b3e]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B3E FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1azv|1azv]], [[1ba9|1ba9]], [[1dsw|1dsw]], [[1fun|1fun]], [[1hl4|1hl4]], [[1hl5|1hl5]], [[1kmg|1kmg]], [[1l3n|1l3n]], [[1mfm|1mfm]], [[1n18|1n18]], [[1n19|1n19]], [[1oez|1oez]], [[1ozt|1ozt]], [[1ozu|1ozu]], [[1p1v|1p1v]], [[1ptz|1ptz]], [[1pu0|1pu0]], [[1rk7|1rk7]], [[1sos|1sos]], [[1spd|1spd]], [[1uxl|1uxl]], [[1uxm|1uxm]], [[2af2|2af2]], [[2c9s|2c9s]], [[2c9u|2c9u]], [[2c9v|2c9v]], [[2v0a|2v0a]], [[2vr6|2vr6]], [[2vr7|2vr7]], [[2vr8|2vr8]], [[2wko|2wko]], [[2wyt|2wyt]], [[2wyz|2wyz]], [[2wz0|2wz0]], [[2wz5|2wz5]], [[2wz6|2wz6]], [[2xjk|2xjk]], [[2xjl|2xjl]], [[4a7g|4a7g]], [[4a7q|4a7q]], [[4a7r|4a7r]], [[4a7s|4a7s]], [[4a7t|4a7t]], [[4a7u|4a7u]], [[4a7v|4a7v]], [[4sod|4sod]]</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b3e OCA], [http://pdbe.org/4b3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b3e RCSB], [http://www.ebi.ac.uk/pdbsum/4b3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b3e ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[http://omim.org/entry/105400 105400]]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>   

[[http://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.  

*[[Superoxide Dismutase|Superoxide Dismutase]]