4a8a: Difference between revisions

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 <SX load='4a8a' size='340' side='right' viewer='molstar' caption='[[4a8a]], [[Resolution|resolution]] 14.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4a8a]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A8A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4A8A FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4a8a]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli] and [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A8A FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kxx|1kxx]], [[2ybi|2ybi]], [[1t6v|1t6v]], [[1vds|1vds]], [[1kir|1kir]], [[1yil|1yil]], [[1heo|1heo]], [[1ior|1ior]], [[1ljg|1ljg]], [[1jis|1jis]], [[2w1m|2w1m]], [[1uic|1uic]], [[1ykz|1ykz]], [[1xgq|1xgq]], [[2war|2war]], [[1lj3|1lj3]], [[1dpw|1dpw]], [[8lyz|8lyz]], [[2lyo|2lyo]], [[1g7h|1g7h]], [[1lks|1lks]], [[5lyt|5lyt]], [[1sfb|1sfb]], [[1ir7|1ir7]], [[1xei|1xei]], [[1hel|1hel]], [[1ljf|1ljf]], [[1f10|1f10]], [[1ljk|1ljk]], [[6lyt|6lyt]], [[1zmy|1zmy]], [[2d91|2d91]], [[2xth|2xth]], [[1lze|1lze]], [[1aki|1aki]], [[1yik|1yik]], [[2d6b|2d6b]], [[1lpi|1lpi]], [[1ndg|1ndg]], [[1flw|1flw]], [[4lyt|4lyt]], [[1jit|1jit]], [[1lzn|1lzn]], [[1ja2|1ja2]], [[1wtn|1wtn]], [[2fbb|2fbb]], [[2lym|2lym]], [[1lz9|1lz9]], [[1lse|1lse]], [[1lsm|1lsm]], [[3lym|3lym]], [[7lyz|7lyz]], [[1t3p|1t3p]], [[2bly|2bly]], [[1b0d|1b0d]], [[1her|1her]], [[1ioq|1ioq]], [[1nby|1nby]], [[1qio|1qio]], [[1xgp|1xgp]], [[1ps5|1ps5]], [[1gwd|1gwd]], [[1v7t|1v7t]], [[1h6m|1h6m]], [[1dqj|1dqj]], [[2a7d|2a7d]], [[1z55|1z55]], [[2c8p|2c8p]], [[1lsb|1lsb]], [[1flq|1flq]], [[1jj1|1jj1]], [[2ybl|2ybl]], [[1yqv|1yqv]], [[1hsx|1hsx]], [[2cds|2cds]], [[1hf4|1hf4]], [[1uib|1uib]], [[1ir9|1ir9]], [[1rjc|1rjc]], [[1ic4|1ic4]], [[1ljh|1ljh]], [[1xej|1xej]], [[1ja7|1ja7]], [[1mel|1mel]], [[1ri8|1ri8]], [[1c10|1c10]], [[1lyo|1lyo]], [[2xjw|2xjw]], [[1n4f|1n4f]], [[2w1y|2w1y]], [[1g7m|1g7m]], [[1sf7|1sf7]], [[1lsf|1lsf]], [[1fn5|1fn5]], [[2d4j|2d4j]], [[1c08|1c08]], [[3lyz|3lyz]], [[1bvk|1bvk]], [[1uif|1uif]], [[1vau|1vau]], [[1lma|1lma]], [[1hc0|1hc0]], [[1a2y|1a2y]], [[4lzt|4lzt]], [[1gxv|1gxv]], [[1p2c|1p2c]], [[1ic5|1ic5]], [[1ua6|1ua6]], [[1at5|1at5]], [[1vfb|1vfb]], [[1vat|1vat]], [[1lj4|1lj4]], [[1ja4|1ja4]], [[4lym|4lym]], [[1flu|1flu]], [[1bwh|1bwh]], [[2hfm|2hfm]], [[1io5|1io5]], [[2bpu|2bpu]], [[1lzb|1lzb]], [[1lsc|1lsc]], [[1w6z|1w6z]], [[2ybn|2ybn]], [[3lyo|3lyo]], [[4lyo|4lyo]], [[1kip|1kip]], [[1ic7|1ic7]], [[1lzt|1lzt]], [[2xbr|2xbr]], [[1lys|1lys]], [[1bwj|1bwj]], [[1e8l|1e8l]], [[132l|132l]], [[1sfg|1sfg]], [[1kxw|1kxw]], [[2x0a|2x0a]], [[2c8o|2c8o]], [[1g7l|1g7l]], [[1sf4|1sf4]], [[1yl1|1yl1]], [[1h87|1h87]], [[3lyt|3lyt]], [[1iot|1iot]], [[1dpx|1dpx]], [[1v7s|1v7s]], [[1ja6|1ja6]], [[1ir8|1ir8]], [[1uie|1uie]], [[1lji|1lji]], [[1bwi|1bwi]], [[2iff|2iff]], [[1jj0|1jj0]], [[1rfp|1rfp]], [[1jiy|1jiy]], [[1iee|1iee]], [[1xek|1xek]], [[1at6|1at6]], [[2ydg|2ydg]], [[1mlc|1mlc]], [[2b5z|2b5z]], [[193l|193l]], [[1lsz|1lsz]], [[2ybm|2ybm]], [[1sq2|1sq2]], [[2ybh|2ybh]], [[1vdq|1vdq]], [[1lje|1lje]], [[1b2k|1b2k]], [[2ybj|2ybj]], [[9lyz|9lyz]], [[1uia|1uia]], [[1hen|1hen]], [[1xfp|1xfp]], [[1lsd|1lsd]], [[2blx|2blx]], [[6lyz|6lyz]], [[1nbz|1nbz]], [[1lsg|1lsg]], [[3hfm|3hfm]], [[1ved|1ved]], [[1lyz|1lyz]], [[1uuz|1uuz]], [[2xbs|2xbs]], [[2d4i|2d4i]], [[1fdl|1fdl]], [[1gxx|1gxx]], [[1lzh|1lzh]], [[1jj3|1jj3]], [[1yky|1yky]], [[1kiq|1kiq]], [[1heq|1heq]], [[1uih|1uih]], [[2lzh|2lzh]], [[1kxy|1kxy]], [[2w1l|2w1l]], [[1g7j|1g7j]], [[1bhz|1bhz]], [[1wtm|1wtm]], [[1hep|1hep]], [[1jtt|1jtt]], [[1lza|1lza]], [[3zvq|3zvq]], [[1jpo|1jpo]], [[1j1p|1j1p]], [[1ljj|1ljj]], [[1f0w|1f0w]], [[2w1x|2w1x]], [[1lzg|1lzg]], [[1lzc|1lzc]], [[1rcm|1rcm]], [[1uid|1uid]], [[1bgi|1bgi]], [[1lzd|1lzd]], [[1lcn|1lcn]], [[1hew|1hew]], [[2vb1|2vb1]], [[2aub|2aub]], [[1j1x|1j1x]], [[1ios|1ios]], [[2cgi|2cgi]], [[1uc0|1uc0]], [[1azf|1azf]], [[4lyz|4lyz]], [[1gpq|1gpq]], [[2a6u|2a6u]], [[2d4k|2d4k]], [[1bvx|1bvx]], [[1uig|1uig]], [[4a7d|4a7d]], [[1qtk|1qtk]], [[1lkr|1lkr]], [[1hsw|1hsw]], [[1jto|1jto]], [[5lyz|5lyz]], [[3lzt|3lzt]], [[1ndm|1ndm]], [[1sf6|1sf6]], [[2lyz|2lyz]], [[1fly|1fly]], [[1yl0|1yl0]], [[1j1o|1j1o]], [[2lzt|2lzt]], [[1lsy|1lsy]], [[1uco|1uco]], [[5lym|5lym]], [[1lsa|1lsa]], [[1hem|1hem]], [[1f3j|1f3j]], [[2a7f|2a7f]], [[194l|194l]], [[1lz8|1lz8]], [[1ykx|1ykx]], [[1vdt|1vdt]], [[1lsn|1lsn]], [[1g7i|1g7i]], [[1vdp|1vdp]]</div></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidase_Do Peptidase Do], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.107 3.4.21.107] </span></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidase_Do Peptidase Do], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.107 3.4.21.107] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4a8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a8a OCA], [http://pdbe.org/4a8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a8a RCSB], [http://www.ebi.ac.uk/pdbsum/4a8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a8a ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a8a OCA], [https://pdbe.org/4a8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a8a RCSB], [https://www.ebi.ac.uk/pdbsum/4a8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a8a ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DEGQ_ECOLI DEGQ_ECOLI]] DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP.<ref>PMID:8576051</ref> <ref>PMID:8830688</ref>  [[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
+[[https://www.uniprot.org/uniprot/DEGQ_ECOLI DEGQ_ECOLI]] DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP.<ref>PMID:8576051</ref> <ref>PMID:8830688</ref>  [[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==