SARM1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of SARM1 shows the <scene name='91/918463/Cv/2'>octamer structure</scene> with outer ring dimension of 200A, inner ring of 45A and thickness of 60A<ref>PMID:33053563</ref>. The 3 domains of SARM1 are <scene name='91/918463/Cv/3'>ARM, SAM and TIR</scene>. The <scene name='91/918463/Cv/4'>interaction of the ARM and TIR domains cause</scene> the autoinhibition of SARM1. <scene name='91/918463/Cv1/1'>NAD(+) binding pocket is at the concave side</scene> of the ARM domain. | The 3D structure of SARM1 shows the <scene name='91/918463/Cv/2'>octamer structure</scene> with outer ring dimension of 200A, inner ring of 45A and thickness of 60A<ref>PMID:33053563</ref>. The 3 domains of SARM1 are <scene name='91/918463/Cv/3'>ARM, SAM and TIR</scene>. The <scene name='91/918463/Cv/4'>interaction of the ARM and TIR domains cause</scene> the autoinhibition of SARM1. <scene name='91/918463/Cv1/1'>NAD(+) binding pocket is at the concave side</scene> of the ARM domain. <scene name='91/918463/Cv1/3'>NAD(+)/protein interactions</scene>. | ||
==3D structures of SARM1== | ==3D structures of SARM1== | ||
[[SARM1 3D structures]] | [[SARM1 3D structures]] | ||