Ion channels: Difference between revisions
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[[User:Laura Fountain/Chloride Ion Channel]]<br /> | [[User:Laura Fountain/Chloride Ion Channel]]<br /> | ||
[[Chloride Intracellular Channel Protein 2]]<br /> | [[Chloride Intracellular Channel Protein 2]]<br /> | ||
'''Calcium-activated chloride channel''' or '''anoctamin''' or '''scramblase''' or '''TMEM16''' are important in cell volume regulation and malignancy<ref>PMID:21607626</ref>.<br /> | |||
'''Ligand-Gated Ion Channels''' (LGIC) open or close when binding a ligand like a neurotransmitter<ref>PMID:15288758</ref>.<br /> | '''Ligand-Gated Ion Channels''' (LGIC) open or close when binding a ligand like a neurotransmitter<ref>PMID:15288758</ref>.<br /> | ||
See [[Journal:Acta_Cryst_D:S205979832000772X|Structural evidence for mono- and di-carboxylates binding at pharmacologically relevant extracellular sites of a pentameric ligand gated ion channel]] <ref>doi 10.1107/S205979832000772X</ref> | See [[Journal:Acta_Cryst_D:S205979832000772X|Structural evidence for mono- and di-carboxylates binding at pharmacologically relevant extracellular sites of a pentameric ligand gated ion channel]] <ref>doi 10.1107/S205979832000772X</ref> | ||
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== Disease == | == Disease == | ||
Mutations in sodium channel are involved in arrhythmia<ref>PMID:19377496</ref>, epilepsy<ref>PMID:16075041</ref>, Brugada syndrome and cardiac conduction disease<ref>PMID:18464934</ref>. Many diseases are related to voltage-gated sodium, potassium, chloride, acetylcholine and glycine ion channels<ref>PMID:11310970</ref>. | Mutations in sodium channel are involved in arrhythmia<ref>PMID:19377496</ref>, epilepsy<ref>PMID:16075041</ref>, Brugada syndrome and cardiac conduction disease<ref>PMID:18464934</ref>. Many diseases are related to voltage-gated sodium, potassium, chloride, acetylcholine and glycine ion channels<ref>PMID:11310970</ref>. Mutations in several members of the calcium-activated chloride channels or anoctamin are liked to several diseases: ano-1 to cancer, ano-5 to muscular dystrophy, ano-10 to ataxia and ano-6 to Scott syndrome<ref>PMID:21642943</ref>.<br /> | ||
==Additional Resources== | ==Additional Resources== | ||