3tvt: Difference between revisions

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==Structural basis for Discs Large interaction with Pins==
==Structural basis for Discs Large interaction with Pins==
<StructureSection load='3tvt' size='340' side='right' caption='[[3tvt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3tvt' size='340' side='right'caption='[[3tvt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TVT FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TVT FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dlg1, l(1)dlg1, CG1725 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), raps, pins, CG5692 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dlg1, l(1)dlg1, CG1725 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), raps, pins, CG5692 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvt OCA], [http://pdbe.org/3tvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tvt RCSB], [http://www.ebi.ac.uk/pdbsum/3tvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tvt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvt OCA], [https://pdbe.org/3tvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tvt RCSB], [https://www.ebi.ac.uk/pdbsum/3tvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tvt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG1_DROME DLG1_DROME]] During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.<ref>PMID:10884224</ref> <ref>PMID:12657668</ref> <ref>PMID:1651169</ref>   
[[https://www.uniprot.org/uniprot/DLG1_DROME DLG1_DROME]] During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.<ref>PMID:10884224</ref> <ref>PMID:12657668</ref> <ref>PMID:1651169</ref>   
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drome]]
[[Category: Large Structures]]
[[Category: Doe, C Q]]
[[Category: Doe, C Q]]
[[Category: Johnston, C A]]
[[Category: Johnston, C A]]

Revision as of 08:47, 13 July 2022

Structural basis for Discs Large interaction with PinsStructural basis for Discs Large interaction with Pins

Structural highlights

3tvt is a 2 chain structure with sequence from Drome. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:dlg1, l(1)dlg1, CG1725 (DROME), raps, pins, CG5692 (DROME)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DLG1_DROME] During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.[1] [2] [3]

References

  1. ↑ Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 2000 Jul 7;289(5476):113-6. PMID:10884224
  2. ↑ Mendoza C, Olguin P, Lafferte G, Thomas U, Ebitsch S, Gundelfinger ED, Kukuljan M, Sierralta J. Novel isoforms of Dlg are fundamental for neuronal development in Drosophila. J Neurosci. 2003 Mar 15;23(6):2093-101. PMID:12657668
  3. ↑ Woods DF, Bryant PJ. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell. 1991 Aug 9;66(3):451-64. PMID:1651169

3tvt, resolution 1.60Å

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