Chorismate mutase: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex of CHM with transition state analog shows the CHM structure containing a dimer of pseudosymmetry but only the N-terminal half contains an available active site pocket. The transition state analog is buried in the active site pocket and forms extensive H-bond network with CHM. Arg 49 and Arg 134 which are part of this network are conserved in all the known CHMs<ref>PMID:16499927</ref>. Overlaying the structure of the unliganded CHM with that of the complex shos a movement of the second shell residues Arg 72 and Gln 75 which can allow the entry of the transition state analog to the active site pocket. | The 3D structure of the complex of CHM with transition state analog shows the CHM structure containing a dimer of pseudosymmetry but only the N-terminal half contains an available active site pocket. The <scene name='91/916399/Cv/4'>transition state analog is buried in the active site pocket and forms extensive H-bond network</scene> with CHM. Arg 49 and Arg 134 which are part of this network are conserved in all the known CHMs<ref>PMID:16499927</ref>. Overlaying the structure of the unliganded CHM with that of the complex shos a movement of the second shell residues Arg 72 and Gln 75 which can allow the entry of the transition state analog to the active site pocket. | ||
==Chorismate mutase 3D structures== | ==Chorismate mutase 3D structures== | ||