3rv6: Difference between revisions
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==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group== | ==Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group== | ||
<StructureSection load='3rv6' size='340' side='right' caption='[[3rv6]], [[Resolution|resolution]] 2.04Å' scene=''> | <StructureSection load='3rv6' size='340' side='right'caption='[[3rv6]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3rv6]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3rv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RV6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RVA:3-{[(Z)-1-CARBOXY-2-PHENYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>RVA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VAE:3-{[(E)-1-CARBOXY-2-PHENYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>VAE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RVA:3-{[(Z)-1-CARBOXY-2-PHENYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>RVA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VAE:3-{[(E)-1-CARBOXY-2-PHENYLETHENYL]OXY}-2-HYDROXYBENZOIC+ACID'>VAE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rv7|3rv7]], [[3rv8|3rv8]], [[3rv9|3rv9]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rv7|3rv7]], [[3rv8|3rv8]], [[3rv9|3rv9]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2386c ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2386c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rv6 OCA], [https://pdbe.org/3rv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3rv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rv6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU]] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Bulloch, E M.M]] | [[Category: Bulloch, E M.M]] | ||
[[Category: Chi, G]] | [[Category: Chi, G]] |