3roq: Difference between revisions
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==Crystal structure of human CD38 in complex with compound CZ-46== | ==Crystal structure of human CD38 in complex with compound CZ-46== | ||
<StructureSection load='3roq' size='340' side='right' caption='[[3roq]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3roq' size='340' side='right'caption='[[3roq]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3roq]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3roq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ROQ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=46Z:(2R,3R,4S,5S)-4-FLUORO-3,5-DIHYDROXYTETRAHYDROFURAN-2-YL+2-PHENYLETHYL+HYDROGEN+(S)-PHOSPHATE'>46Z</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=46Z:(2R,3R,4S,5S)-4-FLUORO-3,5-DIHYDROXYTETRAHYDROFURAN-2-YL+2-PHENYLETHYL+HYDROGEN+(S)-PHOSPHATE'>46Z</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yh3|1yh3]], [[3rok|3rok]], [[3rom|3rom]], [[3rop|3rop]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yh3|1yh3]], [[3rok|3rok]], [[3rom|3rom]], [[3rop|3rop]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3roq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roq OCA], [https://pdbe.org/3roq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3roq RCSB], [https://www.ebi.ac.uk/pdbsum/3roq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3roq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3roq" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3roq" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Hao, Q]] | [[Category: Hao, Q]] | ||
[[Category: Lee, H C]] | [[Category: Lee, H C]] |