1hhh: Difference between revisions

Revision as of 18:51, 2 May 2008

THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2

OverviewOverview

Complexes of five peptides (from HIV-1, influenza A virus, HTLV-1, and hepatitis B virus proteins) bound to the human class I MHC molecule HLA-A2 have been studied by X-ray crystallography. While the peptide termini and their second and C-terminal anchor side chains are bound similarly in all five cases, the main chain and side chain conformations of each peptide are strikingly different in the center of the binding site, and these differences are accessible to direct TCR recognition. Each of the central peptide residues is seen to point up for some bound peptides, but down or sideways for others. Thus, although fixed at its ends, the structure of an MHC-bound peptide appears to be a highly complex function of its entire sequence, potentially sensitive to even small sequence differences. In contrast, MHC structural variation is relatively limited. These results offer a structural framework for understanding the role of nonanchor peptide side chains in both peptide-MHC binding affinity and TCR recognition.

About this StructureAbout this Structure

1HHH is a Protein complex structure of sequences from Hepatitis b virus and Homo sapiens. The following page contains interesting information on the relation of 1HHH with [Major Histocompatibility Complex]. Full crystallographic information is available from OCA.

ReferenceReference

The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2., Madden DR, Garboczi DN, Wiley DC, Cell. 1993 Nov 19;75(4):693-708. PMID:7694806 Page seeded by OCA on Fri May 2 18:51:01 2008

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OCA

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 [[Image:1hhh.jpg|left|200px]]
- {{Structure
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 '''THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2'''
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 [[Category: Madden, D R.]]
 [[Category: Wiley, D C.]]
-[[Category: histocompatibility antigen]]
+[[Category: Histocompatibility antigen]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:51:01 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:04:58 2008''