1hh2: Difference between revisions

Revision as of 18:50, 2 May 2008

CRYSTAL STRUCTURE OF NUSA FROM THERMOTOGA MARITIMA

OverviewOverview

The crystal structure of Thermotoga maritima NusA, a transcription factor involved in pausing, termination, and antitermination processes, reveals a four-domain, rod-shaped molecule. An N-terminal alpha/beta portion, a five-stranded beta-barrel (S1 domain), and two K-homology (KH) modules create a continuous spine of positive electrostatic potential, suitable for nonspecific mRNA attraction. Homology models suggest how, in addition, specific mRNA regulatory sequences can be recognized by the S1 and KH motifs. An arrangement of multiple S1 and KH domains mediated by highly conserved residues is seen, creating an extended RNA binding surface, a paradigm for other proteins with similar domain arrays. Structural and mutational analyses indicate that the motifs cooperate, modulating strength and specificity of RNA binding.

About this StructureAbout this Structure

1HH2 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA., Worbs M, Bourenkov GP, Bartunik HD, Huber R, Wahl MC, Mol Cell. 2001 Jun;7(6):1177-89. PMID:11430821 Page seeded by OCA on Fri May 2 18:50:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1hh2.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1hh2 |SIZE=350|CAPTION= <scene name='initialview01'>1hh2</scene>, resolution 2.1&Aring;
+The line below this paragraph, containing "STRUCTURE_1hh2", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= NUSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
+-->
-|DOMAIN=
+{{STRUCTURE_1hh2|  PDB=1hh2  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hh2 OCA], [http://www.ebi.ac.uk/pdbsum/1hh2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hh2 RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF NUSA FROM THERMOTOGA MARITIMA'''
@@ Line 30: / Line 27: @@
 [[Category: Wahl, M C.]]
 [[Category: Worbs, M.]]
-[[Category: termination]]
+[[Category: Termination]]
-[[Category: transcription regulation]]
+[[Category: Transcription regulation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:50:23 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:04:50 2008''