1hdm: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1hdm.jpg|left|200px]] | [[Image:1hdm.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1hdm", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_1hdm| PDB=1hdm | SCENE= }} | |||
}} | |||
'''HISTOCOMPATIBILITY ANTIGEN HLA-DM''' | '''HISTOCOMPATIBILITY ANTIGEN HLA-DM''' | ||
| Line 27: | Line 24: | ||
[[Category: Mosyak, L.]] | [[Category: Mosyak, L.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
[[Category: | [[Category: Histocompatibility protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:44:14 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 18:44, 2 May 2008
HISTOCOMPATIBILITY ANTIGEN HLA-DM
OverviewOverview
The three-dimensional structure of the soluble ecto-domain of HLA-DM has been determined to 2.5 A resolution by X-ray crystallography. HLA-DM has both peptide exchange activity and acts as a chaperone to peptide-free class II MHC molecules. As predicted, the structure is similar to that of classical class II MHC molecules except that the peptide-binding site is altered to an almost fully closed groove. An unusual cavity is found at the center of the region that binds peptides in class II MHC molecules, and a tryptophanrich lateral surface is identified that is a candidate both for binding to HLA-DR, to effect catalysis, and to HLA-DO, an inhibitor.
About this StructureAbout this Structure
1HDM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation., Mosyak L, Zaller DM, Wiley DC, Immunity. 1998 Sep;9(3):377-83. PMID:9768757 Page seeded by OCA on Fri May 2 18:44:14 2008