1hbk: Difference between revisions

Revision as of 18:40, 2 May 2008

ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM

OverviewOverview

Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. The biochemical properties of Plasmodium falciparum ACBP are described together with the 2.0 A resolution crystal structures of a P. falciparum ACBP-acyl-CoA complex and of bovine ACBP in two crystal forms. Overall, the bovine ACBP crystal structures are similar to the NMR structures published previously; however, the bovine and parasite ACBP structures are less similar. The parasite ACBP is shown to have a different ligand-binding pocket, leading to an acyl-CoA binding specificity different from that of bovine ACBP. Several non-conservative differences in residues that interact with the ligand were identified between the mammalian and parasite ACBPs. These, together with measured binding-specificity differences, suggest that there is a potential for the design of molecules that might selectively block the acyl-CoA binding site.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:11491287 Page seeded by OCA on Fri May 2 18:40:10 2008

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OCA

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 [[Image:1hbk.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1hbk |SIZE=350|CAPTION= <scene name='initialview01'>1hbk</scene>, resolution 2.00&Aring;
+The line below this paragraph, containing "STRUCTURE_1hbk", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=COA:Coa+Binding+Site+For+Chain+A'>COA</scene>, <scene name='pdbsite=MYR:Myr+Binding+Site+For+Chain+A'>MYR</scene>, <scene name='pdbsite=NI1:Ni+Binding+Site+For+Residue+A1091'>NI1</scene> and <scene name='pdbsite=NI2:Ni+Binding+Site+For+Residue+A1092'>NI2</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1hbk|  PDB=1hbk  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hbk OCA], [http://www.ebi.ac.uk/pdbsum/1hbk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hbk RCSB]</span>
-}}
 '''ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM'''
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 ==About this Structure==
-HBK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBK OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBK OCA].
 ==Reference==
 Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11491287 11491287]
-[[Category: Plasmodium falciparum]]
-[[Category: Protein complex]]
 [[Category: Aalten, D M.F Van.]]
-[[Category: fatty acid metabolism]]
+[[Category: Fatty acid metabolism]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:40:10 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:01:39 2008''