1h8p: Difference between revisions

Revision as of 18:34, 2 May 2008

BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE

OverviewOverview

Bovine seminal plasma PDC-109 binds to sperm surface choline lipids and promotes sperm capacitation by stimulating the efflux of cholesterol and phospholipids. The structure of PDC-109 with bound phosphorylcholine was solved using MAD data of a single platinum site. Its two globular (40 x 50 x 20 A(3)) Fn2 domains are linked and clustered by a short polypeptide. The choline binding sites lie at the same face of the molecule. Phosphorylcholine binds to the Fn2 domains through a cation-pi interaction between the quaternary ammonium group and a core tryptophan, plus hydrogen bonding between hydroxyls of exposed tyrosines and the phosphate group. The structure of the PDC-109-oPC complex provides a structural ground for the sperm membrane-coating mechanism underlying PDC-109-induced capacitation.

About this StructureAbout this Structure

1H8P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:11937055 Page seeded by OCA on Fri May 2 18:34:29 2008

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OCA

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 [[Image:1h8p.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1h8p |SIZE=350|CAPTION= <scene name='initialview01'>1h8p</scene>, resolution 1.82&Aring;
+The line below this paragraph, containing "STRUCTURE_1h8p", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Poc+Binding+Site+For+Residue+A1111'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1h8p|  PDB=1h8p  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8p OCA], [http://www.ebi.ac.uk/pdbsum/1h8p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h8p RCSB]</span>
-}}
 '''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''
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 [[Category: Romero, A.]]
 [[Category: Wah, D A.]]
-[[Category: phosphorylcholine-binding protein]]
+[[Category: Phosphorylcholine-binding protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:34:29 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:00:05 2008''