3pb6: Difference between revisions
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==Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.5== | ==Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.5== | ||
<StructureSection load='3pb6' size='340' side='right' caption='[[3pb6]], [[Resolution|resolution]] 1.05Å' scene=''> | <StructureSection load='3pb6' size='340' side='right'caption='[[3pb6]], [[Resolution|resolution]] 1.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3pb6]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3pb6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PB6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pb4|3pb4]], [[3pb7|3pb7]], [[3pb8|3pb8]], [[3pb9|3pb9]], [[3pbb|3pbb]], [[3pbe|3pbe]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pb4|3pb4]], [[3pb7|3pb7]], [[3pb8|3pb8]], [[3pb9|3pb9]], [[3pbb|3pbb]], [[3pbe|3pbe]]</div></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutaminyl-peptide_cyclotransferase Glutaminyl-peptide cyclotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.5 2.3.2.5] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pb6 OCA], [https://pdbe.org/3pb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pb6 RCSB], [https://www.ebi.ac.uk/pdbsum/3pb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pb6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/QPCTL_HUMAN QPCTL_HUMAN]] Responsible for the biosynthesis of pyroglutamyl peptides.<ref>PMID:18486145</ref> <ref>PMID:21288892</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Glutaminyl-peptide cyclotransferase]] | [[Category: Glutaminyl-peptide cyclotransferase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Chen, Y L]] | [[Category: Chen, Y L]] | ||
[[Category: Chia, C Y]] | [[Category: Chia, C Y]] | ||