3oub: Difference between revisions
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==MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide== | ==MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide== | ||
<StructureSection load='3oub' size='340' side='right' caption='[[3oub]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='3oub' size='340' side='right'caption='[[3oub]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3oub]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3oub]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OUB FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ots|3ots]], [[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oua|3oua]], [[3ouc|3ouc]], [[3oud|3oud]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ots|3ots]], [[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oua|3oua]], [[3ouc|3ouc]], [[3oud|3oud]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oub OCA], [https://pdbe.org/3oub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oub RCSB], [https://www.ebi.ac.uk/pdbsum/3oub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oub ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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==See Also== | ==See Also== | ||
*[[ | *[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Brunzelle, J]] | [[Category: Brunzelle, J]] | ||
[[Category: Kovari, I A]] | [[Category: Kovari, I A]] | ||
Revision as of 13:57, 18 May 2022
MDR769 HIV-1 protease complexed with NC/p1 hepta-peptideMDR769 HIV-1 protease complexed with NC/p1 hepta-peptide
Structural highlights
Publication Abstract from PubMedUnder drug selection pressure, emerging mutations render HIV-1 protease drug resistant, leading to the therapy failure in anti-HIV treatment. It is known that nine substrate cleavage site peptides bind to wild type (WT) HIV-1 protease in a conserved pattern. However, how the multidrug-resistant (MDR) HIV-1 protease binds to the substrate cleavage site peptides is yet to be determined. MDR769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90) was selected for present study to understand the binding to its natural substrates. MDR769 HIV-1 protease was co-crystallized with nine substrate cleavage site hepta-peptides. Crystallographic studies show that MDR769 HIV-1 protease has an expanded substrate envelope with wide open flaps. Furthermore, ligand binding energy calculations indicate weaker binding in MDR769 HIV-1 protease-substrate complexes. These results help in designing the next generation of HIV-1 protease inhibitors by targeting the MDR HIV-1 protease. Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.,Liu Z, Wang Y, Brunzelle J, Kovari IA, Kovari LC Protein J. 2011 Mar 12. PMID:21394574[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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