3cm8: Difference between revisions

<table><tr><td colspan='2'>[[3cm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CM8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3CM8 FirstGlance]. <br>

</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3cm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cm8 OCA], [http://pdbe.org/3cm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cm8 RCSB], [http://www.ebi.ac.uk/pdbsum/3cm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cm8 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RDRP_I97A1 RDRP_I97A1]] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.[UniProtKB:P03431]