Troponin: Difference between revisions
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<StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | <StructureSection load='1yv0' size='350' side='right' caption='Chicken troponin: subunit T (dark green), subunit I (wheat), subunit C (pink) complex with Mg+2 ion (green) [[1yv0]]' scene=''> | ||
__TOC__ | |||
== Function == | == Function == | ||
[[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | [[Troponin]] (Tn) is a regulatory protein in muscle contraction. It contains 3 subunits:<br /> | ||
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== Disease == | == Disease == | ||
Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | Mutations in TnI<ref>PMID:9241277</ref> and TnT <ref>PMID:11606294</ref>are associated with hypertrophic cardiomyopathy. | ||
== 3D Structures of Troponin == | |||
[[Troponin 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Troponin == | == 3D Structures of Troponin == | ||
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**[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human<br /> | **[[1j1d]], [[1j1e]], [[4y99]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca - human<br /> | ||
**[[6kn8]], [[6kn7]] - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM<br /> | **[[6kn8]], [[6kn7]] - hTnC + hTnI + hTnT + actin + tropomyosin – Cryo EM<br /> | ||
**[[7ko4]], [[7ko5]], [[7ko7]], [[7kon]], [[7kor]] - pTnC + pTnI + pTnT + actin + tropomyosin – pig - Cryo EM<br /> | |||
**[[6klu]], [[6klt]] - mTnC + TnI + TnT – mouse - Cryo EM<br /> | **[[6klu]], [[6klt]] - mTnC + TnI + TnT – mouse - Cryo EM<br /> | ||
**[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br /> | **[[2w49]], [[2w4u]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br /> | ||
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**[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br /> | **[[2krd]], [[2mkp]] – hTnC+hTnI + Ca – NMR<br /> | ||
**[[6mv3]], [[7jgi]] – hTnC/hTnI (mutant) – NMR<br /> | **[[6mv3]], [[7jgi]] – hTnC/hTnI (mutant) – NMR<br /> | ||
**[[5vln]], [[5wcl]], [[5w88]] – hTnC N-domain (mutant)/hTnI swich region – NMR<br /> | **[[7sc2]], [[7sc3]], [[7sxd]] – hTnC N-domain/hTnI switch region<br /> | ||
**[[5vln]], [[5wcl]], [[5w88]], [[7sxc]] – hTnC N-domain (mutant)/hTnI swich region – NMR<br /> | |||
**[[7kaa]] – hTnC N-domain/hTnI switch region + drug – NMR<br /> | |||
**[[7jgi]], [[7sup]], [[7svc]], [[7swg]], [[7swi]] – hTnC N-domain/hTnI switch region + inhibitor – NMR<br /> | |||
**[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br /> | **[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br /> | ||
**[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | **[[2l1r]] - hTnC C-terminal+hTnI switch region - NMR<br /> | ||