3azh: Difference between revisions

<table><tr><td colspan='2'>[[3azh]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3AZH FirstGlance]. <br>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3afa|3afa]], [[3ayw|3ayw]], [[3aze|3aze]], [[3azf|3azf]], [[3azg|3azg]], [[3azi|3azi]], [[3azj|3azj]], [[3azk|3azk]], [[3azl|3azl]], [[3azm|3azm]], [[3azn|3azn]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3azh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3azh OCA], [http://pdbe.org/3azh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3azh RCSB], [http://www.ebi.ac.uk/pdbsum/3azh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3azh ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>