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==Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution== | ==Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution== | ||
<StructureSection load='6ywt' size='340' side='right'caption='[[6ywt]]' scene=''> | <StructureSection load='6ywt' size='340' side='right'caption='[[6ywt]], [[Resolution|resolution]] 1.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YWT FirstGlance]. <br> | <table><tr><td colspan='2'>[[6ywt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YWT FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ywt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ywt OCA], [https://pdbe.org/6ywt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ywt RCSB], [https://www.ebi.ac.uk/pdbsum/6ywt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ywt ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMP:6-HYDROXYURIDINE-5-PHOSPHATE'>BMP</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ywt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ywt OCA], [https://pdbe.org/6ywt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ywt RCSB], [https://www.ebi.ac.uk/pdbsum/6ywt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ywt ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Krull M]] | [[Category: Krull, M]] | ||
[[Category: Rindfleisch S]] | [[Category: Rindfleisch, S]] | ||
[[Category: Tittmann K]] | [[Category: Tittmann, K]] | ||
[[Category: Bmp]] | |||
[[Category: Lyase]] | |||
[[Category: Ompd]] | |||
[[Category: Orotidine 5'-monophosphate decarboxylase]] | |||
[[Category: Ump]] | |||
Revision as of 15:59, 4 May 2022
Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolutionHuman OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution
Structural highlights
Disease[UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1] References |
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