Methionine synthase: Difference between revisions
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The vitamin B12 Cobalamin binding domain has a special characteristic in that, it is most naturally found in a protective conformation to prevent unwanted chemistry from occurring (PDB: 1BMT). This is referred to as a 'capping' mechanism. | The vitamin B12 Cobalamin binding domain has a special characteristic in that, it is most naturally found in a protective conformation to prevent unwanted chemistry from occurring (PDB: 1BMT). This is referred to as a 'capping' mechanism. | ||
In <scene name='90/907471/Bindingdomain1/1'>scene 1</scene> is the binding domain of Cobalamin, with Cobalt(+1) in pink. | In <scene name='90/907471/Bindingdomain1/1'>scene 1</scene>, this is a 3D visual of the the binding domain of Cobalamin, with Cobalt(+1) in pink. Note here, Cobalamin contains a Corrin ring very similar to what we see in heme. | ||
In <scene name='90/907471/Bindingdomain2/1'>scene 2</scene>, we can see where the DMB ligand exists. During its confirmation change, DMB will move away from the Corrin ring and replaced by His 757. | In <scene name='90/907471/Bindingdomain2/1'>scene 2</scene>, we can see where the DMB ligand exists. During its confirmation change, DMB will move away from the Corrin ring and replaced by His 757. | ||