Sandbox Reserved 1726: Difference between revisions

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OCA, Jaime Prilusky, Elizabeth A. Palumbo, Elizabeth Sutherlin, R. Jeremy Johnson

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 The extracellular ligands of ALK are Anaplastic Lymphoma Kinase Ligand 2 (ALKAL 2) and Anaplastic Lymphoma Kinase Ligand 1 (ALKAL 1) which are polypeptides of 76 and 70 length respectively.
 ==== ALKAL2 ====
-<scene name='90/904331/Alkal2/3'>ALKAL2</scene> is a shared ligand of ALK and LTK. Dimeric ALKAL2 and monomeric ALKAL2-AD both induce dimerization of ALK <ref name="Reshetnyak">PMID:34819673</ref>. Structurally, ALKAL2 has an N-terminal variable region, a conserved augmentor domain, and tends to aggregate in the cell <ref name="Reshetnyak" />. Overexpression of ALKAL2 is linked to high-risk [https://en.wikipedia.org/wiki/Neuroblastoma neuroblastoma] in absence of an ALK mutation <ref name="Borenas">PMID:33411331</ref>.
+<scene name='90/904331/Alkal2/3'>ALKAL2</scene> is a shared ligand of ALK and LTK. Dimeric ALKAL2 and monomeric ALKAL2-AD both induce dimerization of ALK <ref name="Reshetnyak">PMID:34819673</ref>. Structurally, ALKAL2 has an N-terminal variable region, a conserved augmentor domain, and tends to aggregate in the cell <ref name="Reshetnyak" />. ALKAL2, as it binds as a dimer, contains a higher potency of binding to the ALK receptor than the other primary ligand, ALKAL1.<ref name="Reshetnyak2" /> Overexpression of ALKAL2 is linked to high-risk [https://en.wikipedia.org/wiki/Neuroblastoma neuroblastoma] in absence of an ALK mutation <ref name="Borenas">PMID:33411331</ref>.
 ''To return to Structure of ALK with ALKAL2 bound scene click here: <scene name='90/904331/Alk_full/1'>ALK bound to ALKAL2</scene>''
 ==== ALKAL1 ====